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ABSTRACT: Introduction
Rifaximin use in combination with lactulose is associated with a decreased risk of overt hepatic encephalopathy (HE).Methods
We prospectively evaluated the impact of an interruptive electronic medical record alert to indicate rifaximin for patients with cirrhosis and HE on lactulose.Results
The intervention was associated increased rifaximin utilization, particularly for nongastroenterology and hospitalist services odds ratio 1.20 95% confidence interval (1.09-1.31). For patients with HE, the intervention was associated with a lower readmission risk-adjusted subdistribution hazard ratio 0.63 95% confidence interval (0.48-0.82).Discussion
An interruptive alert in the electronic ordering system was associated with a lower risk of readmissions.
SUBMITTER: Louissaint J
PROVIDER: S-EPMC9034761 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Louissaint Jeremy J Grzyb Katie K Bashaw Linda L Mohammad Rima A RA Parikh Neehar D ND Tapper Elliot B EB
The American journal of gastroenterology 20220301 3
<h4>Introduction</h4>Rifaximin use in combination with lactulose is associated with a decreased risk of overt hepatic encephalopathy (HE).<h4>Methods</h4>We prospectively evaluated the impact of an interruptive electronic medical record alert to indicate rifaximin for patients with cirrhosis and HE on lactulose.<h4>Results</h4>The intervention was associated increased rifaximin utilization, particularly for nongastroenterology and hospitalist services odds ratio 1.20 95% confidence interval (1.0 ...[more]