CKD Biomarkers, Cognitive Impairment, and Incident Dementia in an Older Healthy Cohort.

ABSTRACT:

Background

CKD is a risk factor for cognitive impairment (CI), but reports of individual associations of eGFR and albuminuria with CI and incident dementia in healthier, older, longitudinal populations are lacking. Our goal was to estimate these associations in a large cohort of older healthy persons.

Methods

In a longitudinal cohort study of older persons without prior cardiovascular disease, we estimated the associations between baseline eGFR (in ml/min per 1.73 m²) and albuminuria, measured as urine albumin-creatinine ratio (UACR; in mg/mmol) and cognitive test scores, declines in cognitive test scores, and incident dementia using adjusted linear and linear mixed models. Cox proportional hazards regression models assessed the association between baseline kidney

SUBMITTER: Murray AM 

PROVIDER: S-EPMC9034805 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature