Effect of Cyclophosphamide and Glucocorticoid Therapy in IgA Nephropathy: A Single-Center Retrospective Analysis.

ABSTRACT:

Background

IgA nephropathy (IgAN) is the most common primary glomerulonephritis in adults, which causes ESKD in ≤45% of patients in the long term. The optimal therapeutic approach remains undetermined. In this study, we report the results of a single-center retrospective analysis of patients with IgAN.

Methods

We retrospectively evaluated the therapeutic approach and outcome of all patients at our center with biopsy-proven IgAN between 2000 and 2020, focusing on the effect of intravenous cyclophosphamide therapy combined with glucocorticoids ("immunosuppressive therapy group"). The control group received standard supportive care.

Results

Patients in the immunosuppressive therapy group had worse kidney function before the initiation of therapy, as indicated by higher s

SUBMITTER: Beck N 

PROVIDER: S-EPMC9034814 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature