Restless Legs Syndrome in X-linked adrenoleukodystrophy.

ABSTRACT:

Objective/background

X-linked adrenoleukodystrophy (ALD) is a neurodegenerative disease that causes progressive gait and balance problems. Leg discomfort, sleep disturbances, and pain contribute to daily disability. We sought to investigate the prevalence and severity of Restless Legs Syndrome (RLS) in patients with ALD.

Patients/methods

We administered questionnaires and conducted diagnostic telephone interviews to assess RLS severity. We retrospectively extracted data from neurological examinations, functional gait measures, and laboratory assessments.

Results and conclusions

Thirty-two adults with ALD (21 female, 11 male) were recruited to participate. Thirteen patients (40.6%) had RLS (10/21 females and 3/11 males). The median age of RLS onset was 35 years [IQR = 

SUBMITTER: Winkelman JW 

PROVIDER: S-EPMC9035065 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature