Benefits in cardiac function by CD38 suppression: Improvement in NAD⁺ levels, exercise capacity, heart rate variability and protection against catecholamine-induced ventricular arrhythmias.

ABSTRACT: CD38 enzymatic activity regulates NAD⁺ and cADPR levels in mammalian tissues, and therefore has a prominent role in cellular metabolism and calcium homeostasis. Consequently, it is reasonable to hypothesize about its involvement in cardiovascular physiology as well as in heart related pathological conditions.

Aim

To investigate the role of CD38 in cardiovascular performance, and its involvement in cardiac electrophysiology and calcium-handling.

Methods and results

When submitted to a treadmill exhaustion test, a way of evaluating cardiovascular performance, adult male CD38KO mice showed better exercise capacity. This benefit was also obtained in genetically modified mice with catalytically inactive (CI) CD38 and in WT mice treated with antibody 68 (Ab68) which bloc

SUBMITTER: Agorrody G 

PROVIDER: S-EPMC9035106 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature