Changes in extracellular matrix in failing human non-ischemic and ischemic hearts with mechanical unloading.

ABSTRACT: Ischemic and non-ischemic cardiomyopathies have distinct etiologies and underlying disease mechanisms, which require in-depth investigation for improved therapeutic interventions. The goal of this study was to use clinically obtained myocardium from healthy and heart failure patients, and characterize the changes in extracellular matrix (ECM) in ischemic and non-ischemic failing hearts, with and without mechanical unloading. Using tissue engineering methodologies, we also investigated how diseased human ECM, in the absence of systemic factors, can influence cardiomyocyte function. Heart tissues from heart failure patients with ischemic and non-ischemic cardiomyopathy were compared to explore differential disease phenotypes and reverse remodeling potential of left ventricular assisted devic

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9035113 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature