Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC9035118 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Wang Xinming X Ansari Ali A Pierre Valinteshley V Young Kathleen K Kothapalli Chandrasekhar R CR von Recum Horst A HA Senyo Samuel E SE
Advanced healthcare materials 20220218 8
Ischemic heart injury causes permanent cardiomyocyte loss and fibrosis impairing cardiac function. Tissue derived biomaterials have shown promise as an injectable treatment for the post-ischemic heart. Specifically, decellularized extracellular matrix (dECM) is a protein rich suspension that forms a therapeutic hydrogel once injected and improves the heart post-injury response in rodents and pig models. Current dECM-derived biomaterials are delivered to the heart as a liquid dECM hydrogel precur ...[more]