Comparative Effectiveness and Harms of Antibiotics for Outpatient Diverticulitis : Two Nationwide Cohort Studies.

ABSTRACT:

Background

Outpatient diverticulitis is commonly treated with either a combination of metronidazole and a fluoroquinolone (metronidazole-with-fluoroquinolone) or amoxicillin-clavulanate alone. The U.S. Food and Drug Administration advised that fluoroquinolones be reserved for conditions with no alternative treatment options. The comparative effectiveness of metronidazole-with-fluoroquinolone versus amoxicillin-clavulanate for diverticulitis is uncertain.

Objective

To determine the effectiveness and harms of metronidazole-with-fluoroquinolone versus amoxicillin-clavulanate for outpatient diverticulitis.

Design

Active-comparator, new-user, retrospective cohort studies.

Setting

Nationwide population-based claims data on U.S. residents aged 18 to 64 years with priv

SUBMITTER: Gaber CE 

PROVIDER: S-EPMC9035276 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature