Dynamic and progressive changes in thalamic functional connectivity over the first five years of psychosis.

ABSTRACT: The early stage of psychosis (ESP) is a critical period where effective intervention has the most favorable impact on outcomes. Thalamic connectivity abnormalities have been consistently found in psychosis, and are associated with clinical symptoms and cognitive deficits. However, most studies consider ESP patients as a homogeneous population and fail to take the duration of illness into account. In this study, we aimed to capture the progression of thalamic connectivity changes over the first five years of psychosis. Resting-state functional MRI scans were collected from 156 ESP patients (44 with longitudinal data) and 82 healthy controls (24 with longitudinal data). We first performed a case-control analysis comparing thalamic connectivity with 13 networks in the cortex and cerebellum. N

SUBMITTER: Chan SY 

PROVIDER: S-EPMC9035477 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature