Association of Inherited Mutations in DNA Repair Genes with Localized Prostate Cancer.

ABSTRACT:

Background

Identification of germline mutations in DNA repair genes has significant implications for the personalized treatment of individuals with prostate cancer (PrCa).

Objective

To determine DNA repair genes associated with localized PrCa in a diverse academic biobank and to determine genetic testing burden.

Design, setting, and participants

A cross-sectional study of 2391 localized PrCa patients was carried out.

Outcome measurements and statistical analysis

Genetic ancestry and mutation rates (excluding somatic interference) in 17 DNA repair genes were determined in 1588 localized PrCa patients and 3273 cancer-free males. Burden testing within individuals of genetically determined European (EUR) and African (AFR) ancestry was performed between biobank PrCa

SUBMITTER: Lee DJ 

PROVIDER: S-EPMC9035481 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature