The Systemic Lupus Erythematosus Interventional Trials in Mainland China: A Continuous Challenge.

ABSTRACT:

Objectives

More than a quarter of single-country systemic lupus erythematosus (SLE) interventional randomized clinical trials (RCTs) were conducted in China. To help develop management guidelines and set benchmarks for future SLE research, a systematic review of current trials is needed.

Methods

We searched systematically three databases and four registries to summarize the interventional RCTs in mainland China and identify factors associated with participant loss. The internal validity of trials was assessed using the Cochrane risk-of-bias tool for assessing risk of bias. The odds ratio (OR) was defined as the ratio of the odds of less than 10% loss to follow-up in the presence or absence of different factors.

Results

A total of 188 trials met our inclusion criteria,

SUBMITTER: Tian J 

PROVIDER: S-EPMC9035534 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature