The Effect of Endolymphatic Hydrops and Mannitol Dehydration Treatment on Guinea Pigs.

ABSTRACT:

Background

Endolymphatic hydrops (EH) is considered as the pathological correlate of Menière's disease (MD) and cause of hearing loss. The mechanism of EH, remaining unrevealed, poses challenges for formalized clinical trials.

Objective

This study aims to investigate the development of hearing loss, as well as the effect of dehydration treatment on EH animal models.

Methods

In this study, different severity EH animal models were created. The laser Doppler vibrometer (LDV) and auditory brainstem responses (ABR) were used to study the effects of EH and the dehydration effects of mannitol. The LDV was used to measure the vibration of the round window membrane (RWM) reflecting the changes in inner ear impedance. ABR was used to evaluate the hearing changes. Furthermore, t

SUBMITTER: Wang SQ 

PROVIDER: S-EPMC9035551 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature