PSMA as a Theranostic Target in Hepatocellular Carcinoma: Immunohistochemistry and ⁶⁸ Ga-PSMA-11 PET Using Cyclotron-Produced ⁶⁸ Ga.

ABSTRACT: Prostate-specific membrane antigen (PSMA) is a validated target for molecular diagnostics and targeted radionuclide therapy. Our purpose was to evaluate PSMA expression in hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatic adenoma (HCA); investigate the genetic pathways in HCC associated with PSMA expression; and evaluate HCC detection rate with ⁶⁸ Ga-PSMA-11 positron emission tomography (PET). In phase 1, PSMA immunohistochemistry (IHC) on HCC (n = 148), CCA (n = 111), and HCA (n = 78) was scored. In a subset (n = 30), messenger RNA (mRNA) data from the Cancer Genome Atlas HCC RNA sequencing were correlated with PSMA expression. In phase 2, ⁶⁸ Ga-PSMA-11 PET was prospectively performed in patients with treatment-naïve HCC on a digital PET scanner u

SUBMITTER: Thompson SM 

PROVIDER: S-EPMC9035563 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature