Visceral Adiposity and Risk of Stroke: A Mendelian Randomization Study.

ABSTRACT:

Purpose

In recent years, metabolic syndrome has risen in prevalence and brought a heavy disease burden to modern society. As the representative aspect of metabolic syndrome, obesity has been shown to be related to an increased risk of stroke. Given that visceral adipose tissue (VAT) forms the fundamental basis of central obesity, we sought to explore a causal relationship between VAT and stroke by using mendelian randomization (MR) methods.

Methods

Based on two large genome-wide association studies (GWAS) including 325,153 and 35,762 cases of VAT and stroke, respectively, we conducted a MR study which has the inherent advantage of reducing the noise of confounding and reverse causation.

Results

VAT had a significant causal association with ischemic stroke (OR, per 1kg

SUBMITTER: Xu R 

PROVIDER: S-EPMC9035635 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature