Chronic stress increases transcriptomic indicators of biological aging in mouse bone marrow leukocytes.

ABSTRACT: Research with animals and humans has demonstrated that chronic stress exposure can impact key biological aging pathways such as inflammation and DNA damage, suggesting a mechanism through which stress may increase risk for age-related disease. However, it is less clear whether these effects extend to other hallmarks of the aging process, such as cellular senescence. Male SCID mice were exposed to 14 days of restraint stress, with (n ​= ​6) or without (n ​= ​10) propranolol administration, or a non-stress control condition (n ​= ​10). Normal femoral bone marrow leukocytes were isolated from engrafted leukemia cells that had been injected prior to the stressor, as the mice were also under a cancer challenge. We performed whole genome transcriptional profiling to assess i

SUBMITTER: Rentscher KE 

PROVIDER: S-EPMC9035650 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature