Dynamic interplay between thalamic activity and Cajal-Retzius cells regulates the wiring of cortical layer 1.

ABSTRACT: Cortical wiring relies on guidepost cells and activity-dependent processes that are thought to act sequentially. Here, we show that the construction of layer 1 (L1), a main site of top-down integration, is regulated by crosstalk between transient Cajal-Retzius cells (CRc) and spontaneous activity of the thalamus, a main driver of bottom-up information. While activity was known to regulate CRc migration and elimination, we found that prenatal spontaneous thalamic activity and NMDA receptors selectively control CRc early density, without affecting their demise. CRc density, in turn, regulates the distribution of upper layer interneurons and excitatory synapses, thereby drastically impairing the apical dendrite activity of output pyramidal neurons. In contrast, postnatal sensory-evoked activi

SUBMITTER: Genescu I 

PROVIDER: S-EPMC9035679 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature