Update and validation of a diagnostic model to identify prevalent malignant lesions in esophagus in general population.

ABSTRACT:

Background

Previous risk prediction models taking esophageal malignant lesions detected during endoscopy as the primary outcome are not always sufficient to identify prevalent cases which are "overlooked" at screening. We aimed to update and externally validate our previous risk prediction model for malignant esophageal lesions by redefining the predicted outcome.

Methods

15,192 individuals from the Endoscopic Screening for Esophageal Cancer in China randomized controlled trial (ESECC trial, NCT01688908) were included as the training set, and 4576 participants from another population-based esophageal squamous cell carcinoma (ESCC) screening cohort (Anyang Esophageal Cancer Cohort Study, AECCS) served as the external validation set. Lesions with severe dysplasia or worse diag

SUBMITTER: Liu M 

PROVIDER: S-EPMC9035729 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature