Inflammatory Blood Biomarker Kynurenine Is Linked With Elevated Neuroinflammation and Neurodegeneration in Older Adults: Evidence From Two 1H-MRS Post-Processing Analysis Methods.

ABSTRACT:

Rationale and objectives

Pro-inflammatory processes have been argued to play a role in conditions associated with cognitive decline and neurodegeneration, like aging and obesity. Only a limited number of studies have tried to measure both peripheral and central biomarkers of inflammation and examined their interrelationship. The primary aim of this study was to examine the hypothesis that chronic peripheral inflammation would be associated with neurometabolic changes that indicate neuroinflammation (the combined elevation of myoinositol and choline), brain gray matter volume decrease, and lower cognitive functioning in older adults.

Materials and methods

Seventy-four older adults underwent bio-impedance body composition analysis, cognitive testing with the Montreal Cognitive

SUBMITTER: Vints WAJ 

PROVIDER: S-EPMC9035828 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature