Genome-wide Association Study Reveals New Loci Associated With Pyrethroid Resistance in Aedes aegypti.

ABSTRACT: Genome-wide association studies (GWAS) use genetic polymorphism across the genomes of individuals with distinct characteristics to identify genotype-phenotype associations. In mosquitoes, complex traits such as vector competence and insecticide resistance could benefit from GWAS. We used the Aedes aegypti 50k SNP chip to genotype populations with different levels of pyrethroid resistance from Northern Brazil. Pyrethroids are widely used worldwide to control mosquitoes and agricultural pests, and their intensive use led to the selection of resistance phenotypes in many insects including mosquitoes. For Ae. aegypti, resistance phenotypes are mainly associated with several mutations in the voltage-gated sodium channel, known as knockdown resistance (kdr). We phenotyped th

SUBMITTER: Cosme LV 

PROVIDER: S-EPMC9035894 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature