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Bioceramic Scaffolds with Antioxidative Functions for ROS Scavenging and Osteochondral Regeneration.

ABSTRACT: Osteoarthritis (OA) is a degenerative disease that involves excess reactive oxygen species (ROS) and osteochondral defects. Although multiple approaches have been developed for osteochondral regeneration, how to balance the biochemical and physical microenvironment in OA remains a big challenge. In this study, a bioceramic scaffold by 3D printed akermanite (AKT) integrated with hair-derived antioxidative nanoparticles (HNPs)/microparticles (HMPs) for ROS scavenging and osteochondral regeneration has been developed. The prepared bioscaffold with multi-mimetic enzyme effects, which can scavenge a broad spectrum of free radicals in OA, can protect chondrocytes under the ROS microenvironment. Importantly, the bioscaffold can distinctly stimulate the proliferation and maturation of chondrocytes due to the stimulation of the glucose transporter pathway (GLUT) via HNPs/HMPs. Furthermore, it significantly accelerated osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). In vivo results showed that the bioscaffold can effectively enhance the osteochondral regeneration compared to the unmodified scaffold. The work shows that integration of antioxidant and mechanical properties via the bioscaffold is a promising strategy for osteochondral regeneration in OA treatment.

SUBMITTER: Deng C

PROVIDER: S-EPMC9036007 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Bioceramic Scaffolds with Antioxidative Functions for ROS Scavenging and Osteochondral Regeneration.

Deng Cuijun C Zhou Quan Q Zhang Meng M Li Tian T Chen Haotian H Xu Chang C Feng Qishuai Q Wang Xin X Yin Feng F Cheng Yu Y Wu Chengtie C

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20220219 12

Osteoarthritis (OA) is a degenerative disease that involves excess reactive oxygen species (ROS) and osteochondral defects. Although multiple approaches have been developed for osteochondral regeneration, how to balance the biochemical and physical microenvironment in OA remains a big challenge. In this study, a bioceramic scaffold by 3D printed akermanite (AKT) integrated with hair-derived antioxidative nanoparticles (HNPs)/microparticles (HMPs) for ROS scavenging and osteochondral regeneration ...[more]

PMID: 35182053

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Dataset Information

Bioceramic Scaffolds with Antioxidative Functions for ROS Scavenging and Osteochondral Regeneration.

Publications

Bioceramic Scaffolds with Antioxidative Functions for ROS Scavenging and Osteochondral Regeneration.

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