Grandmaternal exercise improves metabolic health of second-generation offspring.

ABSTRACT:

Objective

A major factor in the growing world-wide epidemic of obesity and type 2 diabetes is the increased risk of transmission of metabolic disease from obese mothers to both first (F1) and second (F2) generation offspring. Fortunately, recent pre-clinical studies demonstrate that exercise before and during pregnancy improves F1 metabolic health, providing a potential means to disrupt this cycle of disease. Whether the beneficial effects of maternal exercise can also be transmitted to the F2 generation has not been investigated.

Methods

C57BL/6 female mice were fed a chow or high-fat diet (HFD) and housed in individual cages with or without running wheels for 2 wks before breeding and during gestation. Male F1 offspring were sedentary and chow-fed, and at 8-weeks of age we

SUBMITTER: Alves-Wagner AB 

PROVIDER: S-EPMC9036117 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature