Sex disparities in influenza: A multiscale network analysis.

ABSTRACT: Sex differences in the pathogenesis of infectious diseases because of differential immune responses between females and males have been well-documented for multiple pathogens. However, the molecular mechanism underlying the observed sex differences in influenza virus infection remains poorly understood. In this study, we used a network-based approach to characterize the blood transcriptome collected over the course of infection with influenza A virus from female and male ferrets to dissect sex-biased gene expression. We identified significant differences in the temporal dynamics and regulation of immune responses between females and males. Our results elucidate sex-differentiated pathways involved in the unfolded protein response (UPR), lipid metabolism, and inflammatory responses, includi

SUBMITTER: Wang C 

PROVIDER: S-EPMC9036134 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature