Molecular grading of ductal carcinoma in situ of the breast.

ABSTRACT:

Purpose

Increased incidence of ductal carcinoma in situ (DCIS) associated with mammographic screening for breast cancer has emphasized the challenges of managing this condition. The aim of this study was to identify informative clinical indicators of DCIS biology by molecular profiling.

Experimental design

Areas of in situ carcinoma, atypical ductal hyperplasia, and benign epithelium were microdissected from 46 invasive breast cancers. Oligonucleotide probes showing differential expression between DCIS associated with grade 1 and 3 invasive cancer were identified by microarray-based gene expression profiling. Expression at these probes was used to define a "molecular grade" subcategorization of all samples. The genomic basis of molecular grade was examined by array-based com

SUBMITTER: Balleine RL 

PROVIDER: S-EPMC9036316 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature