Use of lipid-lowering therapy after ischaemic stroke and expected benefit from intensification of treatment.

ABSTRACT:

Objectives

Elevated low-density lipoprotein cholesterol (LDL-C) increases the risk of recurrent cardiovascular disease (CVD) events. We examined use of lipid-lowering therapy (LLT) following ischaemic stroke, and estimated benefits from guideline-based up-titration of LLT.

Methods

The Norwegian COgnitive Impairment After STroke (Nor-COAST) study, a multicentre prospective cohort study, collected data on LLT use, dose intensity and LDL-C levels for 462 home-dwelling patients with ischaemic stroke. We used the Secondary Manifestations of Arterial Disease-Reduction of Atherothrombosis for Continued Health (SMART-REACH) model to estimate the expected benefit of up-titrating LLT.

Results

At discharge, 92% received LLT (97% statin monotherapy). Patients with prestroke demen

SUBMITTER: Gynnild MN 

PROVIDER: S-EPMC9036470 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature