Cognitive Dysfunction in Repeat Expansion Diseases: A Review.

ABSTRACT: With the development of the sequencing technique, more than 40 repeat expansion diseases (REDs) have been identified during the past two decades. Moreover, the clinical features of these diseases show some commonality, and the nervous system, especially the cognitive function was affected in part by these diseases. However, the specific cognitive domains impaired in different diseases were inconsistent. Here, we survey literature on the cognitive consequences of the following disorders presenting cognitive dysfunction and summarizing the pathogenic genes, epidemiology, and different domains affected by these diseases. We found that the cognitive domains affected in neuronal intranuclear inclusion disease (NIID) were widespread including the executive function, memory, information processin

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9036481 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature