Radiation therapy related cardiac disease risk in childhood cancer survivors: Updated dosimetry analysis from the Childhood Cancer Survivor Study.

ABSTRACT:

Background and purpose

We previously evaluated late cardiac disease in long-term survivors in the Childhood Cancer Survivor Study (CCSS) based on heart radiation therapy (RT) doses estimated from an age-scaled phantom with a simple atlas-based heart model (H_Atlas). We enhanced our phantom with a high-resolution CT-based anatomically realistic and validated age-scalable cardiac model (H_Hybrid). We aimed to evaluate how this update would impact our prior estimates of RT-related late cardiac disease risk in the CCSS cohort.

Methods

We evaluated 24,214 survivors from the CCSS diagnosed from 1970 to 1999. RT fields were reconstructed on an age-scaled phantom with H_Hybrid and mean heart dose (D_m), percent volume receiving ≥ 20 Gy (V

SUBMITTER: Shrestha S 

PROVIDER: S-EPMC9036604 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature