Development of a magnetically aligned regenerative tissue-engineered electronic nerve interface for peripheral nerve applications.

ABSTRACT: Peripheral nerve injuries can be debilitating to motor and sensory function, with severe cases often resulting in complete limb amputation. Over the past two decades, prosthetic limb technology has rapidly advanced to provide users with crude motor control of up to 20° of freedom; however, the nerve-interfacing technology required to provide high movement selectivity has not progressed at the same rate. The work presented here focuses on the development of a magnetically aligned regenerative tissue-engineered electronic nerve interface (MARTEENI) that combines polyimide "threads" encapsulated within a magnetically aligned hydrogel scaffold. The technology exploits tissue-engineered strategies to address concerns over traditional peripheral nerve interfaces including poor axonal sampling th

SUBMITTER: Kasper M 

PROVIDER: S-EPMC9036633 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature