Long-term effect of additional rehabilitation following botulinum toxin-A on upper limb activity in chronic stroke: the InTENSE randomised trial.

ABSTRACT:

Background

It is common for people with persistent spasticity due to a stroke to receive an injection of botulinum toxin-A in the upper limb, however post-injection intervention varies.

Aim

To determine the long-term effect of additional upper limb rehabilitation following botulinum toxin-A in chronic stroke.

Method

An analysis of long-term outcomes from national, multicenter, Phase III randomised trial with concealed allocation, blinded measurement and intention-to-treat analysis was carried out. Participants were 140 stroke survivors who were scheduled to receive botulinum toxin-A in any muscle(s) that cross the wrist because of moderate to severe spasticity after a stroke greater than 3 months ago, who had completed formal rehabilitation and had no significant cogn

SUBMITTER: Lannin NA 

PROVIDER: S-EPMC9036685 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature