Impact of chronic co-infection in pulmonary Mycobacterium avium complex disease after treatment initiation.

ABSTRACT:

Background

The impact of co-infection with other pathogenic microorganisms after initiation of treatment for Mycobacterium avium complex pulmonary disease (MAC-PD) has not been clearly described. This study sought to clarify the clinical outcomes of co-infection with MAC after antimycobacterial therapy for MAC.

Methods

Co-infection status was defined as the detection of pathogenic microorganisms other than MAC in at least two consecutive sputum cultures 6-24 months after initiation of treatment. Chest computed tomography (CT) findings and culture results were compared between co-infection and MAC alone groups.

Results

The co-infection and MAC alone groups comprised 12 and 36 patients, respectively. The proportion of patients with sputum culture positive for MAC after

SUBMITTER: Urabe N 

PROVIDER: S-EPMC9036801 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature