GLUT4 gene rs5418 polymorphism is associated with increased coronary heart disease risk in a Uygur Chinese population.

ABSTRACT:

Background

To explore possible associations between glucose transporter 4 (GLUT4) genetic polymorphisms in the patients with coronary heart disease (CHD) in Han and Uygur Chinese populations in Xinjiang, China.

Methods

Two GLUT4 polymorphisms (rs5418 and rs5435) were genotyped in 1262 Han (628 CHD patients and 634 healthy controls) and 896 Uyghur (397 CHD patients and 499 healthy controls) Chinese populations.

Results

In the Han Chinese population, there were no significant differences in allelic or genotypic distribution of rs5418 and rs5435 between the CHD and control groups (all P > 0.05). However, in the Uygur population, there were significant differences in genotype and allele distributions for rs5418 between CHD and the control group (all P < 0.05). Binary Logi

SUBMITTER: Yu F 

PROVIDER: S-EPMC9036804 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature