Betaine host-guest complexation with a calixarene receptor: enhanced in vitro anticancer effect.

ABSTRACT: p-Sulfonatocalix[n]arenes have shown excellent potential for accommodating chemotherapeutic drugs through host-guest complexation and enhancing their anticancer activity. Betaine has been reported to exert an anticancer effect at high concentrations. In order to increase its concentration in cancer cells, we have complexed it with p-SC4, which releases its content in an acidic environment typical of cancer tissue. In this work, a host-guest complex of the chemically stable, natural, and safe active methyl donor (betaine) and p-sulfonatocalix[4]arenes (p-SC4) was designed and characterized using ¹H NMR, UV, Job's plot analysis, DFT calculations, and molecular modeling for use in cancer therapeutics. The peak amplitude of the prepared host-guest

SUBMITTER: Fahmy SA 

PROVIDER: S-EPMC9036920 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature