Maternal soybean genistein on prevention of later-life breast cancer through inherited epigenetic regulations.

ABSTRACT: Breast cancer has strong developmental origins and maternal nutrition composition may influence later-life breast cancer risk in the offspring. Our study focused on a bioactive dietary component, genistein (GE) enriched in soybean products, to investigate specific timing of maternal GE exposure that may influence preventive efficacy of GE on offspring breast cancer later in life, and to explore the potential epigenetic mechanisms. Our results indicate a time-dependent effect of maternal GE exposure on early-life breast cancer development in offspring mice. Through integrated transcriptome and methylome analyses, we identified several candidate genes showing significantly differential gene expression and DNA methylation changes. We further found maternal long-term GE treatment can induce in

SUBMITTER: Chen M 

PROVIDER: S-EPMC9036993 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature