Sex-Specific Differences in MicroRNA Expression During Human Fetal Lung Development.

ABSTRACT: Background: Sex-specific differences in fetal lung maturation have been well described; however, little is known about the sex-specific differences in microRNA (miRNA) expression during human fetal lung development. Interestingly, many adult chronic lung diseases also demonstrate sex-specific differences in prevalence. The developmental origins of health and disease hypothesis suggests that these sex-specific differences in fetal lung development may influence disease susceptibility later in life. In this study, we performed miRNA sequencing on human fetal lung tissue samples to investigate differential expression of miRNAs between males and females in the pseudoglandular stage of lung development. We hypothesized that differences in miRNA expression are present between sexes in ear

SUBMITTER: Lin NW 

PROVIDER: S-EPMC9037032 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature