Detection of SARS-CoV-2 and its S and N proteins using surface enhanced Raman spectroscopy.

ABSTRACT: The COVID-19 pandemic demonstrated the critical need for accurate and rapid testing for virus detection. This need has generated a high number of new testing methods aimed at replacing RT-PCR, which is the golden standard for testing. Most of the testing techniques are based on biochemistry methods and require chemicals that are often expensive and the supply might become scarce in a large crisis. In the present paper we suggest the use of methods based on physics that leverage novel nanomaterials. We demonstrate that using Surface Enhanced Raman Spectroscopy (SERS) of virion particles a very distinct spectroscopic signature of the SARS-CoV-2 virus can be obtained. We demonstrate that the spectra are mainly composed by signals from the spike (S) and nucleocapsid (N) proteins. It is believe

SUBMITTER: Sanchez JE 

PROVIDER: S-EPMC9037103 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature