Immune durability and protection against SARS-CoV-2 re-infection in Syrian hamsters.

ABSTRACT: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a pandemic. As immunity to endemic human coronaviruses (i.e. NL63 or OC43) wanes leading to re-infection, it was unknown if SARS-CoV-2 immunity would also decline permitting repeat infections. Recent case reports confirm previously infected individuals can become re-infected; however, re-infection may be due to heterogeneity in the initial infection or the host immune response, or may be the result of infection with a variant strain that escapes pre-existing immunity. To control these variables, we utilized the Syrian hamster model to evaluate the duration of immunity and susceptibility to re-infection with SARS-CoV-2. Hamsters were given a primary mock or SARS-CoV-2 infection (culture media or 10⁵ TCID50 US

SUBMITTER: Field CJ 

PROVIDER: S-EPMC9037228 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature