Uptake of carbon nanodots into human AML cells in comparison to primary hematopoietic cells.

ABSTRACT: Carbon nanodots (CNDs) comprise a class of next generation nanomaterials with a wide variety of potential applications. Here, we report on their uptake into primary hematopoietic cells from three normal donors and malignant cells from five patients with de novo acute myeloid leukemia (AML). A significant CND uptake was observed in all cell types of the normal and leukemic cells. Still, the uptake was significantly smaller for the CD34⁺ and CD33⁺ myeloid subsets of the malignant cell population as compared to the normal blood-derived CD34⁺ and CD33⁺ cells. For the T and B lymphoid cell populations as defined by CD3 and CD19 within the leukemic and normal samples a similar uptake was observed. The CNDs accumulate preferentially in small clus

SUBMITTER: Nollmann C 

PROVIDER: S-EPMC9037386 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature