Spatial Clustering of Vaccine Exemptions on the Risk of a Measles Outbreak.

ABSTRACT:

Objectives

Areas of increased school-entry vaccination exemptions play a key role in epidemics of vaccine-preventable diseases in the United States. California eliminated nonmedical exemptions in 2016, which increased overall vaccine coverage but also rates of medical exemptions. We examine how spatial clustering of exemptions contributed to measles outbreak potential pre- and postpolicy change.

Methods

We modeled measles transmission in an empirically calibrated hypothetical population of youth aged 0 to 17 years in California and compared outbreak sizes under the observed spatial clustering of exemptions in schools pre- and postpolicy change with counterfactual scenarios of no postpolicy change increase in medical exemptions, no clustering of exemptions, and lower populati

SUBMITTER: Gromis A 

PROVIDER: S-EPMC9037455 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature