A Multi-Omics Study of Familial Lung Cancer: Microbiome and Host Gene Expression Patterns.

ABSTRACT:

Background

Inherited susceptibility and environmental carcinogens are crucial players in lung cancer etiology. The lung microbiome is getting rising attention in carcinogenesis. The present work sought to investigate the microbiome in lung cancer patients affected by familial lung cancer (FLC) and indoor air pollution (IAP); and further, to compare host gene expression patterns with their microbiome for potential links.

Methods

Tissue sample pairs (cancer and adjacent nonmalignant tissue) were used for 16S rRNA (microbiome) and RNA-seq (host gene expression). Subgroup microbiome diversities and their matched gene expression patterns were analyzed. Significantly enriched taxa were screened out, based on different clinicopathologic characteristics.

Results

Our FLC micro

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9037597 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature