Palladium-catalyzed dehydrogenative C-H cyclization for isoindolinone synthesis.

ABSTRACT: In this paper Pd-catalyzed intramolecular dehydrogenative C(sp³)-H amidation for the synthesis of isoindolinones is described. This method features the use of a Pd/C catalyst and the addition of a stoichiometric amount of oxidant is not necessary. A mechanistic study suggested the possible formation of H₂ gas during the reaction.

SUBMITTER: Abe M 

PROVIDER: S-EPMC9037686 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature