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Palladium-catalyzed dehydrogenative C-H cyclization for isoindolinone synthesis.

ABSTRACT: In this paper Pd-catalyzed intramolecular dehydrogenative C(sp³)-H amidation for the synthesis of isoindolinones is described. This method features the use of a Pd/C catalyst and the addition of a stoichiometric amount of oxidant is not necessary. A mechanistic study suggested the possible formation of H₂ gas during the reaction.

SUBMITTER: Abe M

PROVIDER: S-EPMC9037686 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Palladium-catalyzed dehydrogenative C-H cyclization for isoindolinone synthesis.

Abe Masahiro M Ueta Kaho K Tanaka Saki S Kimachi Tetsutaro T Inamoto Kiyofumi K

RSC advances 20210808 43

In this paper Pd-catalyzed intramolecular dehydrogenative C(sp<sup>3</sup>)-H amidation for the synthesis of isoindolinones is described. This method features the use of a Pd/C catalyst and the addition of a stoichiometric amount of oxidant is not necessary. A mechanistic study suggested the possible formation of H<sub>2</sub> gas during the reaction. ...[more]

PMID: 35479970

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