Striatal Cholesterol Precursors Are Altered with Age in Female Huntington's Disease Model Mice.

ABSTRACT:

Background

Cholesterol is necessary for proper neurodevelopment and neuronal health. The brain relies on neural and astrocytic de novo cholesterol synthesis. Huntington's disease presents with altered levels of cholesterol precursors however it is unknown when the disruption in this molecular pathway occurs and whether Manganese (Mn) may alter these metabolic alterations.

Objective

To examine the effect of Mn exposure on cholesterol biosynthesis in pre-manifest and manifest Huntington's disease mice.

Methods

12-week (pre-manifest) male and female and 42-week old (manifest) female YAC128 and littermate control (WT) mice received 3 subcutaneous Mn or vehicle injections. Animals were sacrificed 24 hours after the final injection and striatum, cerebral cortex and cerebell

SUBMITTER: Pfalzer AC 

PROVIDER: S-EPMC9037763 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature