Molecular aspects of Chikungunya virus infections in cancer patients.

ABSTRACT:

Background

Chikungunya virus (CHIKV) is an arbovirus that can cause chronic and debilitating manifestations. The first autochthonous case in Rio de Janeiro state was diagnosed in 2015, and an outbreak was declared in 2016.

Objective

The aim of this work was to evaluate CHIKV viral load in serum, plasma and urine in cancer patients to determine the best sample for diagnosis, as well as perform molecular characterisation and phylogenetic analysis of circulating strains.

Methods

Paired serum, plasma and urine collected from 31 cancer patients were tested by real-time quantitative polymerase chain reaction (qPCR) and a segment of the CHIKV E1 gene was sequenced.

Findings

We detected 11 CHIKV+ oncological patients. Paired samples analyses of nine patients showed a d

SUBMITTER: Familiar-Macedo D 

PROVIDER: S-EPMC9037814 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature