Multi-Omics Analysis of Western-style Diet Increased Susceptibility to Experimental Colitis in Mice.

ABSTRACT:

Background

Western-style diet (WSD) is associated with inflammatory bowel disease (IBD) prevalence. However, the impact of WSD on IBD development and its underlying mechanism remain unclear. Transcriptomics and metabolomics could be beneficial for identifying key factors in WSD-related experimental IBD susceptibility. However, no such study has been conducted yet. We aimed to analyze the implications of WSD for experimental colitis susceptibility in mice and its underlying mechanism using these high-throughput technologies.

Methods

We fed experimental mice a WSD and a control diet from weaning. After 9 weeks, the mice were treated with 2,4,6 trinitrobenzene sulfonic acid to induce colitis, and the control group was treated with 50% ethanol (commonly used IBD animal model). G

SUBMITTER: Lin L 

PROVIDER: S-EPMC9037890 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature