Prefrontal hyperactivation during dual-task walking related to apathy symptoms in older individuals.

ABSTRACT: Increasing evidence associates apathy with worsening in cognitive performance and greater risk of dementia, in both clinical and healthy older populations. In older adults with neurocognitive disorders, apathy has also been related to specific fronto-subcortical structural abnormalities, thus differentiating apathy and major depressive disorder. Yet, the neural mechanisms associated with apathy in healthy older adults are still unclear. In the present study, we investigated the frontal cortical response during a dual-task walking paradigm in forty-one healthy older adults with and without apathy symptoms, controlling for depressive symptoms. The dual-task walking paradigm included a single cognitive task (2-back), a single motor task (walking), and a dual-task condition (2-back whilst walk

SUBMITTER: Talamonti D 

PROVIDER: S-EPMC9037904 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature