Chromogranin A plasma levels predict mortality in COVID-19.

ABSTRACT:

Background

Chromogranin A (CgA) and its fragment vasostatin I (VS-I) are secreted in the blood by endocrine/neuroendocrine cells and regulate stress responses. Their involvement in Coronavirus 2019 disease (COVID-19) has not been investigated.

Methods

CgA and VS-I plasma concentrations were measured at hospital admission from March to May 2020 in 190 patients. 40 age- and sex-matched healthy volunteers served as controls. CgA and VS-I levels relationship with demographics, comorbidities and disease severity was assessed through Mann Whitney U test or Spearman correlation test. Cox regression analysis and Kaplan Meier survival curves were performed to investigate the impact of the CgA and VS-I levels on in-hospital mortality.

Results

Median CgA and VS-I levels were hig

SUBMITTER: De Lorenzo R 

PROVIDER: S-EPMC9037919 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature