Experimental Schistosoma japonicum-induced pulmonary hypertension.

ABSTRACT:

Background

Schistosomiasis, a major cause of pulmonary arterial hypertension (PAH) worldwide, is most clearly described complicating infection by one species, Schistosoma mansoni. Controlled exposure of mice can be used to induce Type 2 inflammation-dependent S. mansoni pulmonary hypertension (PH). We sought to determine if another common species, S. japonicum, can also cause experimental PH.

Methods

Schistosome eggs were obtained from infected mice, and administered by intraperitoneal sensitization followed by intravenous challenge to experimental mice, which underwent right heart catheterization and tissue analysis.

Results

S. japonicum sensitized and challenged mice developed PH, which was milder than that following S. mansoni sensitization and challenge. The degre

SUBMITTER: Kassa B 

PROVIDER: S-EPMC9037943 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature