Targeting metabolic pathways for extension of lifespan and healthspan across multiple species.

ABSTRACT: Metabolism plays a significant role in the regulation of aging at different levels, and metabolic reprogramming represents a major driving force in aging. Metabolic reprogramming leads to impaired organismal fitness, an age-dependent increase in susceptibility to diseases, decreased ability to mount a stress response, and increased frailty. The complexity of age-dependent metabolic reprogramming comes from the multitude of levels on which metabolic changes can be connected to aging and regulation of lifespan. This is further complicated by the different metabolic requirements of various tissues, cross-organ communication via metabolite secretion, and direct effects of metabolites on epigenetic state and redox regulation; however, not all of these changes are causative to aging. Studies in

SUBMITTER: Parkhitko AA 

PROVIDER: S-EPMC9038119 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature