FMRI Food Cue Reactivity as a Predictor for BMI Change Following Roux-en-Y Gastric Bypass (RYGB) or Diet Intervention.

ABSTRACT: Prevalence of severe obesity continues to increase, with only bariatric surgery showing long-term efficacy for sustained weight loss. Individuals with severe obesity (vs normal weight) show greater fMRI responsivity to high energy dense (ED) vs low ED food cues and reduced responsivity post-surgery. We examined responsivity to high vs low ED cues pre-intervention in association with postsurgical (RYGB) or dietary weight-loss (dWL) change in BMI at 4 and 18 mo. Region of interest (ROI) analysis employed separate ANCOVA models; group as single factor with three levels and baseline activation and interaction with group covarying for age and gender as nuisance covariates. Significant results were identified at p < 0.1 false discovery rate (FDR) corrected, following multiple comparisons across

SUBMITTER: Baboumian S 

PROVIDER: S-EPMC9038145 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature