Potential Impact of Cancer Susceptibility Genes on Lung Cancer Metastasis.

ABSTRACT:

Background

Studies of prognosis-related molecular markers are an important tool to uncover the mechanism of tumour metastasis. Cancer susceptibility gene testing is an important tool for genetic counselling of cancer risk. However, the impact of lung cancer susceptibility genes (LCSGs) on lung cancer metastasis and prognosis has not been well studied.

Methods

The list of lung cancer susceptibility genes was retrospectively analysed and updated. After expression profiling and functional analysis, LCSG-based signatures for prognosis were identified by Cox regression and LASSO regression analyses. For translational purposes, nomograms integrating LCSGs and clinical characteristics were constructed.

Results

A total of 301 LCSGs were employed for modelling. For lung adenoc

SUBMITTER: Wang J 

PROVIDER: S-EPMC9038395 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature