IL-36 cytokines imprint a colitogenic phenotype on CD4⁺ T helper cells.

ABSTRACT: IL-36 cytokines are emerging as potent orchestrators of intestinal inflammation and are being implicated in the pathogenesis of inflammatory bowel diseases (IBD). However, the mechanisms through which these cytokines mediate these effects remain to be fully uncovered. Here, we report specifically elevated expression of IL-36α, and not IL-36β or IL-36γ in the serum of newly diagnosed, treatment naïve, paediatric IBD patients and identify T cells as primary cellular mediators of IL-36 responses in the inflamed gut. IL-36R expression on CD4⁺ T cells was found to promote intestinal pathology in a murine model of colitis. Consistent with these effects, IL-36R can act as a potent instructor of CD4⁺ T cell differentiation in vivo, enhancing Th1 responses, while inhibiting th

SUBMITTER: Leon G 

PROVIDER: S-EPMC9038530 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature