Association of soluble Flt-1 with heart failure and cardiac morphology: The MESA angiogenesis study.

ABSTRACT:

Background

Soluble Fms-like tyrosine kinase 1 (sFlt-1) may inhibit angiogenesis. Higher levels of sFlt-1 are associated with worse prognosis in prevalent heart failure patients. The aim of this study was to better understand the role of sFlt-1 in heart failure pathogenesis by characterizing relationships between sFlt-1, cardiac morphology, and the composite outcome of incident heart failure or cardiovascular (CV) death in in a multiethnic cohort free of CV disease at baseline.

Methods

sFlt-1 was measured in 1,381 participants in the Multi-Ethnic Study of Atherosclerosis Angiogenesis sub-study. Linear regression was used to estimate the association between sFlt-1 and cardiac morphology and Cox proportional hazard regression was used to estimate associations with incident hear

SUBMITTER: Berardi C 

PROVIDER: S-EPMC9038636 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature